Currently under construction in the Andean Altiplano, Northern Chile, the Atacama Large Millimeter Array (ALMA) is an international radio interferometer with about 7000 m2 of collecting area comprised of up to 64 12-m antennas. Initially covering the most interesting spectral wavelength ranges from 3 to 0.4 mm, ALMA will be a revolutionary telescope providing astronomy with the first detailed view of the dark and youngest objects of the Universe. The scientific preparations for ALMA are being extremely active since the birth of the project. The various science committees, groups of astronomers working for ALMA, and regional communities interested in the project meet regularly to exchange ideas about the scientific capabilities and first observations to be carried out with the interferometer. A first world-wide conference on "Science with the Atacama Large Millimeter Array" took place in Washington, D.C. (USA), on 6-8 October 1999. The conference to be held in Madrid (Spain), on 13-16 November 2006, will be the second world-wide meeting on "Science with the Atacama Large Millimeter Array". This international ALMA conference is envisioned as a way for the astronomers interested on ALMA, not necessarily radioastronomers, to exchange views, to plan preparatory observations in view of the scientific exploitation of the interferometer, and to obtain the information needed to orient their scientific work to the best possible use of ALMA. The conference will cover a wide range of topics, which will indeed include the main scientific drivers of ALMA: the formation and evolution of galaxies, the physics and chemistry of the interstellar medium, and the processes of star and planet formation. Then web page for the symposium is http://www.oan.es/alma2006/ The calendar for the symposium is as follows : a.. November, 2005: First announcement b.. January 15th, 2006: Second announcement (call for contributions). c.. June 15th, 2006: Deadline for contributions. Registration (reduced fee). d.. September 15th, 2006 : Final deadline for registration. Third and final announcement e.. October 31st, 2006: Last chance to modify the abstracts over the web. f.. November 13-16, 2006: Symposium