Following the success of the VSOP(VLBI Space Observatory Programme), the next generation Space-VLBI mission VSOP-2 has been recently approved by ISAS/JAXA with a planned launch date in 2012. The VSOP-2 spacecraft (ASTRO-G) will employ a 9-m off-axis paraboloid antenna with cryogenically cooled receivers operating at 8, 22, and 43 GHz in dual-polarization. A phase-referencing capability is being considered. The maximum baseline length of 25,000 km will yield an angular resolution of 38 micro-arcseconds at 43 GHz. With these unique technical capabilities of ASTRO-G, we aim to approach some of the fundamental problems in modern astronomy and astrophysics. In this talk, the current status of technical development of ASTRO-G and science goals of the mission will be presented.